These common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C13H20O3
Step B: To the solution 3-azidopropoxyl beta-D-mannopyranoside (1030 mg, 3.91 mmol) in acetonitrile (15 ml) was added triethyl orthobenzoate (2.352 ml, 10.17 mmol) followed by TFA (0.030 ml, 0.391 mmol) and in ACN (0.5 mL). The mixture was allowed to stir at room temperature for 1 hour. Rotavap to remove ACN. TFA (10percent in water) (4.28 ml, 5.55 mmol) was added. The mixture was stirred at rt for 2 hours. The residue was purified by column chromatography on silica gel eluting with Ether/CH2Cl2 to give above product as a white solid. 1H NMR (CDCl3, 500 MHz): delta 7.0-8.2 (m, 10H), 5.72 (dd, 1H, J=3.4 Hz, J=1.1 Hz), 5.44 (t, 1H, J=9.6 Hz), 4.79 (d, 1H, J=1.1 Hz), 4.16 (dd, 1H, J=3.4 Hz, J=1.1 Hz), 4.00 (m, 1H), 3.88 (m, 1H), 3.82 (m, 1H), 3.66 (m, 2H), 3.31 (m, 2H), 1.82 (m, 2H).
The synthetic route of (Triethoxymethyl)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lin, Songnian; Yan, Lin; Kekec, Ahmet; Zhu, Yuping; Hunter, David N.; Huo, Pei; Feng, Danqing; Nargund, Ravi P.; Moyes, Christopher R.; Zhao, Zhiqiang; Pipik, Brenda; Pissarnitski, Dmitri; Duffy, Joseph L.; Guidry, Erin N.; US2015/105317; (2015); A1;,
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