Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromo-1,1-dimethoxyethane
Example 74; (IS, 2R) and (IR, 2S)-2-(4-chlorophenyl)-l’-(2-(4-isopropylpiperazin-l-yl)ethyl)spiro [cyclopropane-l,3′-indolin]-2′-oneSynthesis of (IR, 2S) and (IS, 2R)-2-(4-chlorophenyl)-l’-(2,2- dimethoxyethyl)spiro[cyclopropane-l,3′-indolin]-2′-one; To a solution of (IR, 2S) and (I S, 2R)-2-(4-chlorophenyl)spiro[cyclopropane-l,3′-indolin]- 2′-one (135 mg, 1 mmol) in DMF (1 mL) was added KHMDS (0.5 M in THF, 1.1 mL) was dropwise at room temperature. The mixture was stirred for half an hour before adding bromoacetaldehyde dimethyl acetal (95 mg, 0.55 mmol). The mixture was warmed to 50 C and stirred at that temperature for 2 hours. The mixture was poured into water, extracted with ethyl acetate (3 x 15 mL), dried and concentrated under reduced pressure. Purification by flash column chromatography on silica gel, eluting with hexanes-EtOAc (6: 1 and then 4: 1) gave the desire product as colorless oil (268 mg, 75%). LC/MS m/e calcd. for C2oH2oClN03: 3570, observed (M+H)+: 358.7.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; HUANG, Mengwei; FENG, Lichun; HE, Yun; YUN, Hongying; WO2011/69298; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem