These common heterocyclic compound, 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-(2-Methoxyphenoxy)ethylamine
General procedure: Corresponding 3-bromopropoxyaryl (5 mmol, 1 equiv) and amines(7.5 mmol, 1.5 equiv) was dissolved in 30 mL CH3CN. The reaction was purged with argon 3 times and stirred at reflux for 5 h, and then the mixture was cooled to room temperature and added AcOEt. Afte rwashing with brine 3 times, the organic layer was dried over anhydrous Na2SO4, filtered, and evaporated in vacuo. Purification of the crude residue by column chromatography on silica gel afforded target compounds.
The synthetic route of 2-(2-Methoxyphenoxy)ethylamine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chang, Qi; Chen, Zhuo; Hu, Gaoyun; Hu, Liqing; Li, Qianbin; Long, Jing; Bioorganic and medicinal chemistry; vol. 28; 9; (2020);,
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