Some scientific research about 41789-95-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(3-Methoxyphenyl)-N-methylmethanamine, and friends who are interested can also refer to it.

Electric Literature of 41789-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41789-95-1 name is 1-(3-Methoxyphenyl)-N-methylmethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of alpha-bromo~2′-acetonaphthone (386.2 g, 1.57 mol) in dichloromethane (2.5 L) at 00C was added compound 3 (249.1 g, 1.65 mol) in 30 min, followed by the addition of triethylamine (220.7 mL, 1.57 mmol) in 45 min. After stirring at 00C for 40 min, the reaction mixture was warmed to room temperature and stirred overnight. The reaction solution was then washed with water (2x) and the aqueous layer was re-extracted with dichloromethane (2x). The combined organic extract was dried over sodium sulfate and concentrated in vacuo. The ketone, compound 4, was obtained as a reddish oil (513.3 g, quantitative), was used in the next step without further purification: ‘H NMR (CDCl3, 500 MHz) 8.50 (s, IH), 8.01(d, J= 8.5 Hz, IH), 7.92 (d, J = 8.0 Hz, IH), 7.88-7.85 (m, 2H)5 7.60-7.54 (m, 2H), 7.26-7.23 (m, IH), 6.97-6.94 (m, 2H), 6.82 (dd, J- 8.0, 2.5 Hz, IH), 3.88 (s, 2H), 3.75 (s, 3H), 3.69 (s, 2H), 2.42 (s, 3H); ESI MS m/z 320 [M+ H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(3-Methoxyphenyl)-N-methylmethanamine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ALBANY MOLECULAR RESEARCH, INC.; WO2009/149258; (2009); A2;,
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