Reference of 5414-19-7, These common heterocyclic compound, 5414-19-7, name is 1-Bromo-2-(2-bromoethoxy)ethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 8 (1.70 g, 8.015 mmol) was dissolved in N, N-dimethylformamide (20 mL)Placed in a sealed tube,2,2′-dibromodiethyl ether (1.4 mL, 8.816 mmol) and N, N-diisopropylethylamine (2.7 mL, 16.03 mmol) were added.The reaction was heated to 100 C,Stir for 16 hours.Cooled to room temperature,Ethyl acetate was added,Washed,The organic phase is dried,Filtered and concentrated under reduced pressure,The crude product was purified by column chromatography,To give intermediate 9 (2.23 g) in 42% yield.
Statistics shows that 1-Bromo-2-(2-bromoethoxy)ethane is playing an increasingly important role. we look forward to future research findings about 5414-19-7.
Reference:
Patent; Shanghai Hansoh BioMedical Co., Ltd.; Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Zhao, Zhiming; Wu, Chenchen; Yu, Hongping; Xu, Yaochang; Pan, Zhongzong; Bao, Rudi; (26 pag.)CN106349180; (2017); A;,
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