Related Products of 1516-96-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1516-96-7, name is 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
Under nitrogen protection, to a 250 mL dry 3-necked round bottom flask equipped with a magnetic stirrer and thermometer was added:THE was added dropwise to the solution of the residue prepared above under nitrogen at 0C. After stirring another 1.5h at room temperature, the mixture was quenched withwater at 0C and extracted three times withdichloromethane. The combined organic layers were dried over Na2504 and concentrated in vacuo. The residue was purified by flash chromatography on silica gel, eluting with petroleum ether/ethyl acetate = 75:25, to give product as a white solid (1.94 g, 81% yield).1.0 g tetraethyl (((2R)-propane-1,2-diylbis(oxy))bis(3,1-phenylene))bis(phosphonate) (2.0 mmol, 1.0 equiv.) in3.0 mL thionyl chloride (40.0 mmol, 20.0 equiv.) under nitrogen was added30.0 iL dimethylformamide (0.4 mmol, 0.2 equiv). The mixture was stirred under reflux for 18 h, during which time15.0 iL dimethylformamide (all together 8.0 mmol, 0.3 equiv.) was added after 12h. After the solvent was evaporated, the residue was dissolve in5.0 mL THE and concentrated in vacuo (once). The residue was used for the next step without further purification.To a phenyl magnesium bromide solution prepared from a suspension of0.53g magnesium turning (22.0 mmol, 11.0 equiv.) and6.0 g 5-bromo-1,3-di-tert-butyl-2-methoxybenzene (20.0 mmol, 10.0 equiv.) in20.0 mL10.0 mL50 mL
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; DSM IP ASSETS B.V.; BONRATH, Werner; FENG, Zheng-Chuan; MEDLOCK, Jonathan, Alan; PENG, Kun; ZHU, Zhibin; (28 pag.)WO2018/189107; (2018); A1;,
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