Reference of 62415-74-1,Some common heterocyclic compound, 62415-74-1, name is 1,2-Dibromo-4-methoxybenzene, molecular formula is C7H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of Intermediate I-1 (0258) 5.31 g (20.0 mmol) of 1,2-dibromo-4-methoxybenzene, 3.30 g (30.0 mmol) of pyrocatechol, 0.190 g (1.0 mmol) of CuI, 0.264 g (1.0 mmol) of 18-crown-6, and 8.28 g (60.0 mmol) of K2CO3 were dissolved in 150 mL of dimethylformamide (DMF), and stirred at a temperature of about 140 C. for about 24 hours. The solution was cooled to room temperature, 60 mL of water was added thereto, and an organic layer was extracted three times therefrom using 60 mL of diethyl ether. The obtained organic layer was dried using magnesium sulfate (MgSO4), and the MgSO4 was removed by filtration. A solvent was next removed therefrom by evaporation. The obtained residue was separated and purified through silica gel chromatography to produce 3.21 g of Intermediate I-1 (yield: 75%). The obtained compound was identified by liquid chromatography-mass spectrometry (LC-MS). C13H10O3: M+1 215.1
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dibromo-4-methoxybenzene, its application will become more common.
Reference:
Patent; SAMSUNG DISPLAY CO., LTD.; Kim, Youngkook; Jung, Hyejin; Han, Sanghyun; Hwang, Seokhwan; (115 pag.)US2017/77419; (2017); A1;,
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