Related Products of 20012-63-9,Some common heterocyclic compound, 20012-63-9, name is 2-(Benzyloxy)aniline, molecular formula is C13H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of this acid chloride in dry methylene chloride (65 ml) was added to a stirred mixture of 2-benzyloxyaniline [3.0 g; prepared as described by Barber et al., J. Chem. Soc., (1961), 2828], pyridine (1.36 g) and dry methylene chloride (65 ml) at 0 C. The mixture was stirred at 10 C. for 2 hours and then was allowed to stand at room temperature overnight. The mixture was washed twice with water and the methylene chloride solution was then dried over magnesium sulphate and evaporated under diminished pressure. The resulting solid was recrystallized from ethanol to give 1-benzyl-2′-benzyloxy-1H-tetrazole-5-carboxanilide (3.1 g), m.p. 140-142 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Benzyloxy)aniline, its application will become more common.
Reference:
Patent; May & Baker Limited; US4442115; (1984); A;,
Ether – Wikipedia,
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