Adding some certain compound to certain chemical reactions, such as: 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5111-65-9. 5111-65-9
After 2-bromo-6-methoxynaphthalene (200 mg, 0.844 mmol), sodium azide (110 mg, 1.69 mmol), proline (126 mg, 1.10 mmol), and copper(I) oxide (121 mg, 0.844 mmol) were added to degassed DMSO (1.7 ml), this mixture was heated at 100 C. for 11 hours. The reacted solution was cooled to room temperature, and then ethyl acetate and water were introduced thereto. The mixed solution was filtered to remove solid, and then the filtered liquid was layer-separated. The separated organic layer was washed with an aqueous solution of saturated sodium bicarbonate, dried over sodium sulfate, and then concentrated in vacuo. The concentrated solution was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to give an orange solid of 6-methoxynaphthalene-2-amine (77.9 g, 0.450 mmol, 53.3%). 1H-NMR (CDCl3, Varian 400 MHz): delta3.73 (2H, brs), 3.88 (3H, s) , 6.93-6.97 (2H, m) , 7.04-7.08 (2H, m) , 7.51 (1H, d, J=8.8 Hz), 7.57 (1H, d, J=8.8 Hz)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-Bromo-6-methoxynaphthalene.
Reference:
Patent; COLLEGE OF MEDICINE POCHON CHA UNIVERISTY INDUSTRY- ACADEMIC COOPERATION FOUNDATION; CHAMEDITECH CO., LTD.; Yoon, Tae Jong; Chung, Kwang Hoe; Seo, Jeongbeob; Kang, Sin Wook; Lee, Kwang Hyuong; Kwon, Yong Su; Jeon, Hye Sun; Lee, Chae Woon; Kim, Jin sung; US2018/327357; (2018); A1;,
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