These common heterocyclic compound, 54314-84-0, name is ((3-Bromopropoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 54314-84-0
To a solution of Lambda/-[4-(7-Hydroxy-6-methoxy-quinoIin-4-yloxy)-phenyl]-benzamide (0.12g, 0.32mmol) in DMF (3ml) was added potassium carbonate (0.11g, O.deltammol, 2.5eq) and benzyl 3- bromopropyl ether (64ul, 0.36mmol, 1.1 eq). The reaction wasstirred at room temperature for 48 hours. The DMF was removed under reduced pressure and ethyl acetate was added to the crude residue, washing with water. The ethyl acetate layer was dried over magnesium sulphate and evaporated under reduced pressure. The product was purified by column chromatography, eluting with ethyl acetate/heptane (2:1 ) to yield the title compound (0.15g, 90percent) as a yellow solid, m/z 535 [M+H]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54314-84-0.
Reference:
Patent; CHROMA THERAPEUTICS LTD; WO2006/117570; (2006); A1;,
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