19056-40-7, The chemical industry reduces the impact on the environment during synthesis 19056-40-7, name is 4-Bromo-3-methoxyaniline, I believe this compound will play a more active role in future production and life.
To a stirred solution of 4-bromo-3-methoxyaniline (0.5 g, 2.47 mmol) in toluene (5 mL) were added ethylacetoacetate (0.5 mL, 3.71), sodium ethoxide (0.34 g, 4.94 mmol), and heated to110¡ãC for 16 h. After completion of the reaction, the reaction mixture was diluted with EtOAC(100 mL), washed with water (100 mL), brine (100 mL), dried over sodium sulphate andconcentrated. The residue was purified by colunm chromatography by using silica gel (60-120mesh) to afford the title product as yellow solid (0.4 g, 90percent). 1H NMR (400 MHz, DMSO-d6): oe10.21 (s, 1H), 7.48?7.43 (m, 2H), 7.11?7.08 (m, 1H), 3.83 (s, 3H), 3.54 (s, 2H), 2.20 (s, 3H); ES-MS: mlz 286.1 (M-i-1).
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-3-methoxyaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SAMAJDAR, Susanta; ABBINENI, Chandrasekhar; SASMAL, Sanjita; HOSAHALLI, Subramanya; WO2015/104653; (2015); A1;,
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