In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 70627-52-0 as follows. 70627-52-0
General procedure: To a solution of [RhCl(cod)]2(2 mol %) in DMF at room temperature was added imine (1). Then, BF3¡¤Et2O (1.2 equiv) wasadded to the mixture and stirred for 30 min at the same temperature. Subsequently, 5,6-dihydro-2H-pyran-2-one (2, 1.2 equiv)was added to the mixture and then 1.0 MEt2Zn in hexane(3 equiv) was gradually added to the mixture at room temperature, and the mixture was stirred for 24 h. The mixture wasquenched with sat. NH4Cl and extracted with AcOEt. TheAcOEt layer was washed with sat. NaCl and dried over MgSO4.The solvent was removed in vacuo, and the residue was purified by column chromatography to give the corresponding antiazetidin-2-one.
According to the analysis of related databases, 70627-52-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Isoda, Motoyuki; Sato, Kazuyuki; Kunugi, Yurika; Tokonishi, Satsuki; Tarui, Atsushi; Omote, Masaaki; Minami, Hideki; Ando, Akira; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1608 – 1615;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem