A common compound: 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 20781-20-8
b) 3-[2-(2,4-dimethoxybenzylamino)pyridin-4-yl]-/V-(1-methylpiperidin-4- yl)imidazo[1,2-b]pyridazin-6-amineTo a solution of 3-(2-chloropyridin-4-yl)-//-(1-methylpiperidin-4-yl)imidazo[1 ,2-b]pyridazin-6- amine (100 mg, 0.29 mmol) and NaO’Bu (39 mg, 0.41 mmol) in DME (2 mL) was added a pre-mixed solution of Pd(OAc)2 (3 mg, 0.015 mmol) and CyPF-‘Bu (8 mg, 0.015 mmol) in DME (1 mL). The reaction mixture was stirred for 5 min before 2,4-dimethoxybenzylamine (68 mg, 0.41 mmol) was added and the mixture heated at 100C for 18 h. The reaction mixture was concentrated in vacuo and purification by column chromatography (EtOAc-2M NH3 in MeOH gradient) gave an off-white solid (77 mg, 56%); 1H NMR (400 MHz, CD3OD) delta ppm 7.94 (d, J=6.0 Hz, 1H), 7.85 (s, 1 H), 7.62 (d, =9.6 Hz, 1 H), 7.51 (s, 1 H), 7.24 (dd, J=5.7, 1.6 Hz, 1H), 7.21 (d, J=8.2 Hz, 1 H), 6.72 (d, J=9.6 Hz, 1 H), 6.54 (d, J=2.3 Hz, 1 H), 6.46 (dd, J=8.2, 2.3 Hz, 1H), 4.43 (s, 2H), 3.83 (s, 3H), 3.82-3.76 (m, 1H), 3.75 (s, 3H), 2.88-2.77 (m, 2H), 2.23-2.09 (m, 7H), 1.68-1.53 (m, 2H); m/z (ES+APCI)+: 474 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 20781-20-8, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; OSBORNE, Simon; CHAPMAN, Timothy; LARGE, Jonathan; BOULOC, Nathalie; WALLACE, Claire; WO2011/101640; (2011); A1;,
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