In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 20781-20-8
General procedure: The solution of l-(benzyloxy)-6-bromo-3-((2,4-difluorobenzyl)carbamoyl)-2-oxo-l,2-dihydro-l,8- naphthyridin-4-yl 4-methylbenzenesulfonate (7; 0.2 mmol), N-ethyl-N-isopropylpropan-2-amine (2.0 mmol) and amine (1.0 mmol) in DMF (2.0 mL) was heated to 50 C for 1 hr. The reaction mixture was cooled to room temperature and purified by Combiflash. Compound 4-substituted l-(benzyloxy)-6-bromo- N-(2,4-difluorobenzyl)-2-oxo-l,2-dmydro-l,8-naphthyridine-3-carboxamide (8) was afforded.According to general procedure A, the title compound was prepared in 89 % yield from l-(benzyloxy)-6- bromo-3-((2,4-difluorobenzyl)carbamoyl)-2-oxo-l,2-dihydro-l,8-naphthyridin-4-yl 4- methylbenzenesulfonate (7). NMR (400 MHz, CDCI3) delta 12.05 (t, 7 = 6.2 Hz, 1H), 10.61 (t, 7 = 5.7 Hz, 1H), 8.58 (d, 7 = 2.1 Hz, 1H), 8.34 (d, 7 = 2.2 Hz, 1H), 7.57 (dd, 7 = 7.3, 1.9 Hz, 2H), 7.39 – 7.22 (m, 4H), 7.17 (dd, 7 = 8.9, 4.3 Hz, 1H), 6.85 – 6.63 (m, 2H), 6.47 – 6.34 (m, 2H), 5.15 (s, 2H), 4.64 (d, 7 = 6.3 Hz, 2H), 4.52 (d, 7 = 5.7 Hz, 2H), 3.74 (s, 3H), 3.73 (s, 3H)
The synthetic route of 20781-20-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; ZHAO, Xue, Zhi; SMITH, Steven; METIFIOT, Mathieu, A.; JOHNSON, Barry; MARCHAND, Christophe; HUGHES, Stephen; POMMIER, Yves; BURKE, Terrence, R.; WO2014/186398; (2014); A1;,
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