Adding a certain compound to certain chemical reactions, such as: 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20781-20-8, 20781-20-8
Example 162: 3-Fluoro-8-isopropyl-10-methyl-11-oxo-/V-piperidin-4-yl-10,11- dihydrodibenzo[6,f][1 ,4]thiazepine-7-sulfonamide 5,5-dioxide hydrochlorideStep 1. te/f-Butyl 4-(2,4-dimethoxybenzylamino)piperidine-1-carboxylate[0492] A mixture of terf-butyl 4-oxopiperidine-1-carboxylate (21.0 g, 0.105 mol), 2,4-dimethoxybenzylamine (17.6 g, 0.105 mol), and sodium triacetoxyborohydride (55.8 g, 0.263 mol) were stirred in ethanol (500 ml_) 2 hours at room temperature. Aqueous sodium bicarbonate was added, and the mixture was extracted with dichloromethane. The organic phase was washed with brine, dried over magnesium sulfate and concentrated to a volume of 325 ml_ to afford an approximately 0.323 M solution in dichloromethane of terf-butyl 4-(2,4-dimethoxybenzylamino)piperidine-1- -carboxylate which was used without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2,4-Dimethoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; WYETH; WO2008/61029; (2008); A1;,
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