1484-26-0, Adding some certain compound to certain chemical reactions, such as: 1484-26-0, name is 3-Benzyloxyaniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1484-26-0.
2-Ohtoeroethyl isothiocyanate (293 ing, 2.4 mroot) was added io a solution of 3~bepsilonnzy)oxy~pheny)amine (398 mg, 2,0 mmoi) in dicMoromethane (4 mL), The reaction mixture was stirred at room temperature overnight It was quenched with water (30 mL), followed by extraction with diehloromethane OO mL x 3 ), The organic layers were combined, washed with brine, and concentrated under vacuum. The residue thus obtained was subjected to column chromatography on silica gel to give l -(3-benlambda’ioxy-plienyl)-3-{2-chloro-ethyl)-{hioufea (627 mg, 1.96 mmoi. yield; 98percent) as colorless oil.Tricihylarmne (2.0 mL, excess) was added to a solution of i ~(3-be”zyloxy- phctty.)-3-(2-chloro-ethyl)-mionrea ( S 87 mg, 0.58 mmol} in dry THF (3 mL). The reaction mixture was stirred at refluxiog temperature for 6 hours. It was then quenched with a saturated ammonium chloride aqueous solution {30 niL), followed by extraction with ethyl acetate (30 mL x 3), The organic layers were combined, washed with brine, and concentrated under vacuum. The residue thus obtained was subjected Jo column chromatography on silica gei to give l-(3-benz.yloxy~phenyl>- imidazoiidine-2-thione (compound 76) as a white solid (150 mg. 0.52 mmoi, yield: 90percent).Fi-MS (M-M ): 285.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1484-26-0.
Reference:
Patent; NATIONAL HEALTH RESEARCH INSTITUTES; WO2008/22204; (2008); A2;,
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