5961-59-1, The chemical industry reduces the impact on the environment during synthesis 5961-59-1, name is 4-Methoxy-N-methylaniline, I believe this compound will play a more active role in future production and life.
General procedure: To a solution of 2,4-Dichloropyrimidine (1) (0.149g, 1.0 mmol) in 15 mL isopropanol was added 4-methoxy-N-methylaniline derivative (2) (1.0 mmol). The reaction mixture was stirred at room temperature and monitored by TLC. When the reaction was completed, the solvent was removed under vacuum and the slurry was dilute with water (10 mL). The solution was adjusted to pH 9 with a saturated NaHCO3 solution, extracted with ethyl acetate (10 mL¡Á3) for three times, the organic phase was washed with water (10 mL), dried over sodium sulfate, concentrated and purified by column chromatography to give the target compound 3a-3b. 2-Chloro-N-(4-methoxyphenyl)-N-methylpyrimidin-4-amine (3a) White solid. Yield: 79percent. 1H NMR (400 MHz, Chloroform-d) delta 7.85 (d, J = 6.1 Hz, 1H), 7.14 (d, J = 2.2 Hz, 1H), 7.12 (d, J = 2.3 Hz, 1H), 6.99 (d, J = 2.3 Hz, 1H), 6.97 (d, J = 2.2 Hz, 1H), 6.08 (d, J = 6.1 Hz, 1H), 3.85 (s, 3H), 3.44 (s, 3H). 13C NMR (101 MHz, CDCl3) delta 163.86, 160.66, 158.97, 155.98, 136.25, 128.03, 115.50, 103.27, 55.55, 38.35. HRMS (ESI) (m /z) [M+H]+ calcd for C12H12N3OCl, 250.0742; found, 250.0725. Purity: 100.0percent (by HPLC).
The chemical industry reduces the impact on the environment during synthesis 4-Methoxy-N-methylaniline. I believe this compound will play a more active role in future production and life.
Reference:
Article; Xu, Shaoyu; An, Baijiao; Li, Yuxin; Luo, Xunbang; Li, Xingshu; Jia, Xian; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1769 – 1775;,
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