As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929-75-9 name is 1,11-Diamino-3,6,9-trioxaundecane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 929-75-9
The compound 2-(4-(2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxo-piperazin-1-yl)acetic acid (25mg, 0.017mmol), HATU (14.45mg, 0.038mmol), DIPEA (6.1mg, 0.05mmol) was dissolved in dry DMF, the1,11-diamino-3,6,9-trioxaundecane (3.3 mg, 0.017 mmol) was slowly added dropwise to the above solution, and after reacting at room temperature for 1 h,The reaction was detected to be complete. The solvent was distilled off under reduced pressure and purified by silica gel column chromatography (eluent, dichloromethane / methanol = 100/3).18 mg of a pale yellow solid was obtained with a yield of 64.3%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,11-Diamino-3,6,9-trioxaundecane, and friends who are interested can also refer to it.
Reference:
Patent; Second Military Medical University; Sheng Chunquan; Dong Guoqiang; Ma Junhui; He Shipeng; Fang Yuxin; Wu Shanchao; Chen Shuqiang; (19 pag.)CN110563706; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem