1535-73-5, A common heterocyclic compound, 1535-73-5, name is 3-Trifluoromethoxyaniline, molecular formula is C7H6F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of a-7 (0.001 mol), meta- (OCF3)-aniline (0.0015 mol), supported cyano-borohydride (0.0021 mol) and acetic acid (6 drops) in methanol was stirred at room temperature for 48 hours, and then filtered. The filtrate was evaporated. The residue was taken up in CH2Cl2/methanol. The organic layer was washed with a solution of K2C03 10percent, dried over magnesium sulfate, filtered and the solvent was evaporated. The residue (0.42g) was purified by column chromatography over silica gel (eluent: CH2Ck/CH30H/NH4OH 93/7/0. 5 ; 15-35 pm). The pure fractions were collected and the solvent was evaporated. The residue (0. 15g, 32percent) was crystallized from CH3CN/methanol. The precipitate was filtered off and dried, yielding 0.085g (18percent, compound 4, melting point: 156¡ãC) of 2-{2-Amino-6-[(3-trifluoromethoxy- phenylamino)-methyl]-benzoimidazol-1-ylmethyl}-6-methyl-pyridin-3-ol.
The synthetic route of 1535-73-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/58869; (2005); A1;,
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