Adding a certain compound to certain chemical reactions, such as: 1515-81-7, name is 1-Methoxy-4-(methoxymethyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1515-81-7, 1515-81-7
General procedure: Toan oven-dried round-bottomed flask under N2 atmosphere was added CH2Cl2(5 mL), the ketone (1.0 mmol), 2,6-lutidine (164 mL, 151 mg, 1.40 mmol) and TMSOTf (271 muL, 333 mg, 1.50mmol). The mixture was cooled to 0 Cand p-methoxybenzyl methyl ether (167mL, 167 mg, 1.10 mmol) was added. The reaction mixture was allowed to warmslowly to ambient temperature and stirred for 16 h, then it was passed througha column of silica (2 cm x 1 cm) with Et2O. The solvent was removedin vacuo and the residue was purified by column chromatography (0-5%EtOAc/hexanes).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methoxy-4-(methoxymethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Downey, C. Wade; Covington, Sarah E.; Obenschain, Derek C.; Halliday, Evan; Rague, James T.; Confair, Danielle N.; Tetrahedron Letters; vol. 55; 37; (2014); p. 5213 – 5215;,
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