1535-73-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1535-73-5, name is 3-Trifluoromethoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 3 (4-TERT-BUTYL-PHENYL)- {4- [2- (4-TRIFLUOROMETHYL-PIPERIDIN-1-YL)-PYRIMIDIN-4-YL]-ISOQUINOLIN- 1-YL}-AMINE To a solution of (4-TERT-BUTYLPHENYL)- [4- (2-CHLOROPYRIMIDIN-4-YL)-ISOQUINOLIN-1-YL] AMINE (0.07 g, 1.80 x 104 m) in n-butanol (30 mL) is added 4-trifluoromethylpiperdine (0.07 g, 4. 57 x 104 m) and triethylamine (0. 50 mL). The mixture is heated to 100¡ãC for 16 hours and then allowed to cool to room temperature. The mixture is concentrated in vacuo and then dissolved in methylene chloride (75 mL). The organic phase is washed with a saturated solution of sodium bicarbonate, brine, dried over magnesium sulfate and concentrated to a oil. The oil is purified by flash chromatography (SIO2 : 75percent hexanes/25percent ethyl acetate). A light yellow oil is collected and crystallized from ether, m. p. 179-180¡ãC. CHN analysis calc. percent C: 68.89 ; percent H: 5.98 ; percent N: 13.85. Found percent C: 68.91 ; percent H: 5.73 ; percent N: 13.73.
The synthetic route of 1535-73-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/28444; (2005); A1;,
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