Brief introduction of 4-Bromo-3-methoxyaniline

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19056-40-7 as follows. 19056-40-7

Example A5; a) Preparation of intermediate compound 7; A solution of methyl chloroglyoxalate (0.0593 mol) in CH2Cl2 (50 ml) was added por- tionwise to a mixture of 4-bromo-3-methoxybenzenamine (0.0494 mol) and Et3N (0.0741 mol) in CH2Cl2 (50 ml), stirred at 0 0C. The resultant reaction mixture was stirred for 24 hours at room temperature. A saturated aqueous NaHCO3 solution was added. The organic layer was separated, dried (Na2SO4), filtered and the solvent was evaporated. The residue was treated with diethyl ether, subsequently filtered off and dried. Yield: 12.8 g of intermediate compound 7 (91 percent).

According to the analysis of related databases, 19056-40-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/71646; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem