134364-69-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 134364-69-5, name is 2,3-Difluoroanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In 0 C next, the anhydrous aluminum chloride (1.82g, 13mmol) is added to 5-bromo-2-chlorobenzene formyl chloride 12b (3.4g, 13 . 4mmol, see example 12 step 1) and 1,2-difluoro-3-methoxybenzene 14b (2.4g, 16 . 7mmol) in dichloromethane (40 ml) in a mixed solution, in 0 C reaction under 16 hours. Maintain 0 C using hydrochloric acid solution (4 ml, 8mmol, 2M) quenching the reaction, the resulting mixture of natural temperature raising to room temperature, with methylene chloride (40 ml ¡Á 4) extraction, combined with the phase. The organic phase is dried with anhydrous sodium sulfate, filtered, filtrate concentrated to obtain title compound 14c crude product of (5.4g, yellow liquid), yield: 96.4%. The crude product is directly used for the next step synthesis.
The synthetic route of 2,3-Difluoroanisole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Gu, Zheng; Wen, Jiaping; Tang, Wanjun; Wang, Weihua; Deng, Bingchu; Wu, Wuyong; Qu, Tong; (100 pag.)CN105461762; (2016); A;,
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