In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1484-26-0 as follows. 1484-26-0
A mixtureof triethyl orthoformate (92 mL, 0.55 mol) and 2,2-dimethyl- [1, 3] – dioxane-4,6-dione (75.3 g, 0.522 mol) (Meldrum’s acid) was heated at55 C for 90 minutes and then cooled to45 C. A solution of 3-benzyloxyaniline (100.2 g, 0.5029 mol) in methanol (200 mL) was slowly added to the reaction over a period 45 minutes while maintaining the reaction temperature below50 C. The reaction was then heated at45 C for one hour, allowed to cool to room temperature, and stirred overnight. The reaction mixture was cooled to 1 C, and the product was isolated by filtration and washed with cold ethanol (-400 mL) until the filtrate was colorless.5-{[(3- Benzyloxy) phenylimino]methyl}-2,2-dimethyl- [1, 3] -dioxane-4,6-dione (170.65 g) was isolated as a tan, powdery solid. ‘H NMR (300MHz, DMSO-d6) : 8 11.21 (d, J= 14.2 Hz, 1H), 8. 61 (d, J= 14.2 Hz, 1H), 7.49-7. 30 (m, 7H), 7.12 (dd, J= 8. 1,1. 96 Hz, 1H), 6.91 (dd, J= 8.4, 2.1 Hz, 1H), 5.16 (s, 2H), 1. 68 (s, 6H).
According to the analysis of related databases, 1484-26-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/48933; (2005); A2;,
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