These common heterocyclic compound, 54314-84-0, name is ((3-Bromopropoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 54314-84-0
Example 25; 5-{(lJ?)-2-[({l-[3-(Benzyloxy)propyl]-4-hydroxypiperidin-4-yl}methyl)amino]-l- hydroxyethyl}-8-hydroxyquinoin-2(lJH)-one; i) l-(3-Benzyloxy-propyl)-piperidin-4-oneA suspension of benzyl 3-bromo-propyl ether (2.29g), 4-piperidinone hydrate hydrochloride (1.69g), potassium carbonate (anhydrous) (3.45g) and potassium iodide (830mg) were stirred in dry DMF (40ml) at 85¡ãC and continued for 24 h. The reaction was poured into water (200 mL plus brine 25 mL) and extracted with EtOAc. The organic extract was evaporated and the residue was chromatographed on silica gel eluting with 4:3 EtOAc/isohexane giving the sub-titled compound as a colourless oil. Yield: 1.8g 1U NMR (300Mz, CDCl3) delta 7.39 – 7.32 (4H, m), 7.31 – 7.25 (IH, m), 4.52 (2H, d), 3.60 – 3.53 (2H, m), 2.79 – 2.70 (4H, m), 2.61 – 2.54 (2H, m), 2.48 – 2.41 (4H, m), 1.89 – 1.80 (2H, m)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54314-84-0.
Reference:
Patent; ASTRAZENECA AB; WO2007/102771; (2007); A1;,
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