Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-19-7, name is 1-Bromo-2-ethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., 583-19-7
3-(2-bromoacetyl)-8-chloro-2H-chromen-2-one (150 mg, 0.54 mmol) and l-bromo-2-ethoxybenzene (108 mg, 0.54 mmol) were reacted in a microwave in the presence of CS2CO3 (528 mg, 1.62 mmol), Pd2(dba)3 (40mg, 0.054mmol.), xantphose (60mg, 0.108mmol), and dioxane (2 mL) at 160C for 15 minutes. The resulting product was then purified by pre-HPLC to yield 8-chloro-3-(2-(2-ethoxyphenylamino)thiazol-4-yl)-2H-chromen-2-one (20 mg, 10%) as a yellow solid. ESI-MS (EI+, m/z): 399.1 [M+l]+; 1HNMR (500 MHz, DMSO-<): delta 1.40 (t, J = 7 Hz, 3H), 4.14 (q, J= 7 Hz, 2H), 6.99-7.05 (m, 3H), 7.39 (t, J = 8 Hz, 1H), 7.76-7.79 (m, 2H), 7.93 (t, J= 7 Hz, 1H), 8.48-8.49 (m, 1H), 8.65 (s, 1H), 9.54 (s, 1H).
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Reference:
Patent; DISCOVERYBIOMED, INC.; SCHWIEBERT, Erik; STREIFF, John; DIXON, John; GAO, Hongwu; WO2014/152213; (2014); A2;,
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