651734-54-2, Adding a certain compound to certain chemical reactions, such as: 651734-54-2, name is 2,6-Difluoro-3,5-dimethoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 651734-54-2.
In a 500-mL round bottom flask, 3.00 g (15.86 mmol) of 2,6-difluoro- 3,5-dimethoxy-phenylamine and 3.13 g (15.86 mmol) of 4-ethylamino-2-methylsulfanyl- pyrimidine-5-carbaldehyde in 150 ml_ of toluene with 1.11 g (4.76 mmol) of camphorsulfonic acid was fitted with a Dean Stark trap and heated at reflux. During the day, the toluene was drained 3 times from the finger, replenished with 100 mL of the solvent and continued heating at reflux under nitrogen atmosphere overnight. The toluene was concentrated in vacuo and dried to give 7.19 g (quantitative) of the title compound. No further purification was necessary. MS (APCI) (m+1)/z 369.1.
According to the analysis of related databases, 651734-54-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2006/38112; (2006); A1;,
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