62257-15-2,Some common heterocyclic compound, 62257-15-2, name is 2-Fluoro-5-methoxyaniline, molecular formula is C7H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 3: 2-(2-Fluoro-5-methoxv-phenvlamiotano-4-(2-methanesulfonvl-phenylamiotano)- py?miotadiotane-5-carboxyliotac acid amide (3); Step a: 2-(2-Fluoro-5-methoxy-phenylamiotano)-6-oxo-1 ,6-diotahydro-rhoy?miotadiotane-5-carboxyliotac acid ethyl ester (3a); A mixture of 2-methylsulfonyl-6-oxo-1 ,6-diotahydro-py?miotadiotane-5-carboxyliotac acid ethyl ester (CA Reg No 53554-29-3, 108 mg) and 2-fluoro-5-methoxy-aniotaliotane (CA Reg No 62257-15-2, 90 mg) is heated without solvent in an oil bath of 160 0C After 2h the reaction is cooled, and the residue is crystallized from methanol affording 3a (UPLC method C, tret 1 93 mm, MS 308/ES+)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Fluoro-5-methoxyaniline, its application will become more common.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2008/9458; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem